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The use of drugs of the tetracycline class during tooth development (pregnancy, infancy and childhood to the age of 12 years) may cause permanent discolouration of the teeth (yellow-grey-brown). Do not use in adolescents where adult teeth are not fully developed. Use with caution in patients receiving potentially hepatotoxic drugs- patients showing symptoms of hepatotoxicity (jaundice, nausea, vomiting, abdominal pain, loss of appetite) should be referred to their GP for liver function test prior to supply of medication. Buy Doxycycline  


Prophylaxis should begin 1-2 days before travel to malarial areas. It should be continued daily during travel in the malarial areas and for 4 weeks after the traveller leaves the malarial area. 100 mg daily in adults and children over the age of 12 years. If gastric irritation occurs, it is recommended that doxycycline is taken with food or milk. Studies indicate that the absorption of doxycycline is not notably influenced by simultaneous ingestion of food or milk.

Side Effects

Any drug may produce unwanted or unexpected adverse reactions. Detection and recording of these is of vital importance. Patients should be actively encouraged to report any suspected adverse reaction, particularly to black triangle medicines All side effect information is taken from relevant product SPCs as referenced in this PGD. Common:

  • Anaphylactic Reaction (including angioedema, exacerbation of systemic lupus erythematosus, pericarditis, hypersensitivity, serum sickness HenochSchonlein Purpura, hypotension, dyspnoea, tachycardia peripheral oedema and urticaria)
  • Headache
  • Nausea/vomiting
  • Photosensitivity reaction
  • Rash including maculopapular and erythematous rashes
  • Uncommon and rare side effects can be found in the PIL or SPC. Healthcare professionals are asked to report any suspected adverse reactions via the Medicines and Healthcare products Regulatory Agency (MHRA), Yellow Card Scheme at or search for MHRA Yellow Card in the Google Play or Apple App Store