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Malarone is a combination medication that contains two medicines: atovaquone and proguanil. It is used for the prevention and treatment of malaria caused by the bites of Anopheles mosquitoes. Malaria parasites usually enter the body through mosquito bites and live in the body tissues such as red blood cells.

16 Tablets ( 1 week trip)
23 Tablets ( 2 week trip)
30 Tablets ( 3 week trip)
37 Tablets ( 4 week trip)
51 Tablets ( 6 week trip)
65 Tablets ( 8 week trip)
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Absorption of atovaquone may be reduced in patients with diarrhoea or vomiting, but diarrhoea or vomiting was not associated with reduced efficacy in clinical trials of Malarone for malaria prophylaxis. However, as with other antimalarial agents, subjects with diarrhoea or vomiting should be advised to continue with malaria prevention measures by complying with personal protection measures (repellants, bed nets).


Using 250mg/100mg strength tablets Adults and children (body-weight 41 kg and above) ONE tablet once daily, to be started 1–2 days before entering endemic area and continued for 1 week after leaving.    

Side Effects

Any drug may produce unwanted or unexpected adverse reactions. Detection and recording of these is of vital importance. Patients should be actively encouraged to report any suspected adverse reaction, particularly to black triangle medicines All side effect information is taken from relevant product SPCs as referenced in this PGD. Very Common:

  • Headache
  • Nausea
  • Vomiting
  • diarrhoea
  • Abdominal Pain
  • Anaemia
  • Neutropenia
  • Allergic reaction
  • Hyponatraemia
  • Anorexia
  • Abnormal dreams
  • Depression
  • Insomnia
  • Dizziness
  • Elevated liver enzymes
  • Pruritis
  • Rash
  • Fever
  • Cough
Uncommon, Rare and ‘Not known’ side effects can be found in the SPC. Patients should be advised to read the patient information leaflet prior to taking medication. Healthcare professionals are asked to report any suspected adverse reactions via the Medicines and Healthcare products Regulatory Agency (MHRA), Yellow Card Scheme at or search for MHRA Yellow Card in the Google Play or Apple App Store